Before starting any new supplement, it's best to first run it by your doctor. But, each of the eight strains in Smidge® Sensitive Probiotic powder has extensive research supporting their safety and efficacy in helping to revitalize your entire body. Smidge® also took into account the rate of growth of these strains, so they would help maintain the balance in your gut. For instance, its histamine- degrading strains balance the histamine-forming strains in the proper ratio. This way, you can maximize your benefits from probiotics while still minimizing your exposure to D-lactate and histamine.